Receptors, Polymeric Immunoglobulin

Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions. They are found on the surfaces of epithelial cells and hepatocytes. After binding to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport by vesicle, and secretion into the lumen by exocytosis. Before release, the part of the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology, 1989)

Year introduced: 1996

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Tree Number(s): D12.776.543.750.705.871.700

MeSH Unique ID: D019056

Entry Terms:

• Polymeric Immunoglobulin Receptors
• Immunoglobulin Receptors, Polymeric
• Receptor, Polyimmunoglobulin
• Receptor, Polymeric Ig
• Poly-Ig Receptor
• Poly Ig Receptor
• Receptor, Poly-Ig
• Polyimmunoglobulin Receptor
• Polymeric Immunoglobulin Receptor
• Immunoglobulin Receptor, Polymeric
• Receptor, Polymeric Immunoglobulin
• Polymeric Ig Receptor
• Ig Receptor, Polymeric

Previous Indexing:

• Receptors, Immunologic (1989-1995)
• Secretory Component (1992-1995)

All MeSH Categories
Chemicals and Drugs Category
Amino Acids, Peptides, and Proteins
Proteins
Membrane Proteins
Receptors, Cell Surface
Receptors, Immunologic
Receptors, Fc
Receptors, Polymeric Immunoglobulin